It depends on where in South Carolina you live. If you live in the Greenville/Spartanburg area, there's the largest deaf population. Columbia has a pretty large group, and Charleston's not bad. If you live in a place like Dillon, there's not much going on.
The link for SCAD, as deafdyke posted, is a good place to start for finding deaf events on the calendar.
Things are pretty much grouped by region--Lowcountry, Midlands, Coastal, and Piedmont/Upstate.
Depending on where you live, you might want to check out the Atlanta area, too.