Future Genetic Engineering Technology?

Lukin

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I read this some years ago about hair cells found in all birds. Apparently, they did an experiment by "burning and killing off the hair cells" in ears.

So they regenerated back like normal. This mean that birds could not ever go deaf.

That would be feasible exploring field for stem cells. Of course, we will probably be 100 years old when this technology would be available to start an instrumental genocide of all deaf community and deaf culture rots off within few years afterwards.

Comments?
 
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If there is a cure found doesn't mean people will take it. There are MANY deaf people who wouldn't take it thus keeping the deaf community stable and not "rotting" off as you put it.
 
If there is a cure found doesn't mean people will take it. There are MANY deaf people who wouldn't take it thus keeping the deaf community stable and not "rotting" off as you put it.

Sorry, I was on the mission to piss off the deaf people. So you see.

But yeah, the possibility of that defiance happening is very significant. Good response!
 
LOL link please?

Oh, boy. It has been years. I am quite sure that the original link has disappeared. But maybe there are others.

Give me a moment.

Well, shit, I just shitted my pants. They have experimented mice with experimental ear cells... successfully restored the deafness. This is as recently as January 2013. Regenerated Hair Cells Restore Hearing Mice | Hearing Loss News and More

The above article's main site is at this: hair cell regeneration | Hearing Loss News and More

I better explore other sites because I'm not so sure of above site's reputation.

Here is a reliable informative NIH site about loss of hair cells in mammals: NIH Fact Sheets - Hair Cell Regeneration and Hearing Loss

Wow, this information not only reveal that birds can regenerate, but fishes as well! Drug could reverse permanent deafness by regenerating hair cells in inner ear | Mail Online

This one mentioned frogs as well. The challenge of hair cell regeneration

Umm okay I better get back to the ORIGINAL source. What is the godsake link?

AHA! I think I have found the original source that I read years ago. Here you go, scientist buffs.

http://www.bsos.umd.edu/PSYC/DOOLING/publications/2001/New%20studies%20on%20hair%20cell%20regeneration%20in%20birds.pdf

It's not that long, but... if you open your mind, you will enlighten yourself as of what futuristic medical technology might be.
 
better and more natural than CI...
is all i can say, but yah science is always for the 'elite' and no one else...
 
Lukin,, doesn't mean that it will work with children. Heck it might not even work with late deafened adults. I remember reading something that stuck with me " One thing you learn in medical school is how little we know about the human body."
Prediction. We will STILL have deafness and hearing loss for thousands more years!
 
I read this some years ago about hair cells found in all birds. Apparently, they did an experiment by "burning and killing off the hair cells" in ears.

So they regenerated back like normal. This mean that birds could not ever go deaf.

That would be feasible exploring field for stem cells. Of course, we will probably be 100 years old when this technology would be available to start an instrumental genocide of all deaf community and deaf culture rots off within few years afterwards.

Comments?

You don't have to believe me or my expierence in medical research but...I worked in a lab that many of those papers are from. (Some people here argue medicine with me...and I really can't reply to them because they don't see a difference between googling and advanced degrees in biomedical research.)
The promise of research along those lines is the theory that you could use a viral vector to introduce the target gene into human cochlae.
The problem is that viral vectors are largely untested, and in this case, the gene is a modification of a ridicuosly important gene that prevents normal cells from turning into cancer.
The preliminary results of the experiments regarding bird cells in mammals has been minor increase in hearing threshold (measured by ABR which just gives a measure of what cells can possibly hear and not what the individual actually hears). If the mice lived long enough they would develop tumors. That is what happens when you knock out p53.

And to DeafDyke, these therapies are directed only to SNHL because other forms of deafness (aural atresia, middle ear malformations, chronic ear infections) can almost always be treated medically.
If one of the treatments the OP referenced was approved, it would likely be decades before it was approved for children since children cannot consent to be part of clinical trials.
So the fact that a treatment wouldn't benefit children isn't really valid unless you ant to change medical ethics.
Also, I know I'll et shit for this, but cochlear implants work really well for congenitally deaf children regardless of whether they are taught using sign or spoken language.

We need to move past the "evil CI is destroying Deaf culture" debate.
 
Sorry, I was on the mission to piss off the deaf people. So you see.

But yeah, the possibility of that defiance happening is very significant. Good response!

and why would you be on that mission?
 
and why would you be on that mission?

Damnit zebras! You are making me look silly for somehow not reading that line and instead distilling a year of my work and a decade of my PIs work into a tiny paragraph...!:roll:
 
Damnit zebras! You are making me look silly for somehow not reading that line and instead distilling a year of my work and a decade of my PIs work into a tiny paragraph...!:roll:

lol sorry..that was the first line I read and I was like :roll:
 
And to DeafDyke, these therapies are directed only to SNHL because other forms of deafness (aural atresia, middle ear malformations, chronic ear infections) can almost always be treated medically.
You misread that. I never asked why these potential therapies are targeted towards SNHL. How the heck did you even get that?
I do think that any cure is going to be a hell of a lot more complex then just repairing stem cells....that's what I meant. I also think it's going to be a LOT easier for late deafened people to benefit from any cure.
And atresia isn't always repairable. There are some cures but very often the surgery just results in improved hearing, and the person still has to wear an aid.
 
Thanks for the links. I just want to make sure that most of us read what you saw.

I do not know what to think about it. if it become popular and no complicate then let others go through this. I am too old for the fad thingy. ha I know it is not a fad thingy maybe I can say, it's a technology thingy.
 
Not to mention, there's too much money in the business for them to have a cure. It's still very pie in the sky. I have a feeling we will have dhh people for thousands more years....if not forever.
 
*Starts injecting bird stem cells into ear*

hmm, it's not working yet??

Seriously, that's interesting. I wonder what makes it different for birds
 
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