OJ Cancels Medication

***VamPyroX*** · 08-20-2008, 02:00 PM

No, I'm not talking about OJ Simpson canceling his medicine prescription...

Drinking fruit juice 'may stop medication working'| News | This is London

Quote:

Drinking fruit juice 'may stop medication working'

Drinking fruit juice dramatically reduces the effectiveness of drugs used to treat cancer, heart conditions and high blood pressure, scientists say.

Research has shown that orange, apple and grapefruit juice can also wipe out the benefits of some antibiotics and hay-fever pills.

It is thought the drinks stop drugs from entering the bloodstream and getting to work in the body - possibly rendering them useless.

The potential effects are so serious, researchers warned, that if in doubt, patients should swap fruit juices for water when on medication.

Researcher David Bailey said: 'This is just the tip of the iceberg. I'm sure we'll find more and more drugs that are affected this way.'

Twenty years ago, Professor Bailey showed that grapefruit juice dangerously magnifies the effect of the blood pressure drug felodipine.

His findings led to warnings that the drink should be avoided by those on some medicines.

The latest study shows that fruit juices can also reduce the power of medicines - potentially stopping them from doing any good.

Professor Bailey, of the University of Western Ontario, in Canada, said: 'The concern is loss of benefit of medications essential for the treatment of serious medications.'

Drugs shown to be weakened by grapefruit, orange and apple juices include the blood pressure-lowering beta blockers atenolol, celiprolol, and talinolol and the hay-fever treatment fexofenadine.

The multi-purpose antibiotic ciprofloxacin, used to combat germs behind food poisoning and bone and joint infections, is also affected.

So is the cancer drug etoposide and a drug given to prevent the rejection of transplanted organs.

Many other drugs are also likely to be affected, an American Chemical Society conference heard yesterday.

The study showed juices do not need to be taken at the same time as drugs to have a dangerous effect.

Those drunk up to two hours before can reduce drug absorption.

But patients need not stop drinking juice altogether.

Professor Bailey said: 'Juice taken four hours prior to drug intake did not have an effect. Thus, it should be possible still to take grapefruit, orange and apple juices while on affected medications provided there is a sufficient time interval.

'I would recommend taking drugs with water on an empty stomach to get the most consistent effect.'

The researcher, a professor of pharmacology, advised patients to speak to their doctor or pharmacist before taking fruit juice with medicines.

Professor Bailey made the link after asking volunteers to take the hay fever drug fexofenadine at the same time as either a glass of water or grapefruit juice.

Taking it with juice cut its absorption into the bloodstream by half.

Experiments showed naringin, the chemical which makes grapefruit taste bitter, blocked the drug from moving from the small intestine into the bloodstream.

The researchers have pinpointed a naringin-like compound in orange juice and are looking for a similar one in apples.

A different mechanism is at play with the drugs whose levels are boosted by grapefruit juice.

There, juice deactivates a liver enzyme that breaks down drugs, making normal doses potential overdoses.

The study is not the first to highlight the dangers behind supposedly healthy juices.

Last month, research from Harvard Medical School in the U.S., showed that one glass of orange juice a day can increase the risk of a form of diabetes linked to poor diet and obesity.

But eating whole pieces of fruit cuts the likelihood of developing the disease. It is thought the lack of fibre in juices may cause spikes in blood sugar levels.

jillio · 08-20-2008, 04:56 PM

Good info, Vampy.

CCfan · 08-20-2008, 05:22 PM

Wow! Great info! Thanks so much for giving a very impro! VamPyroX!

Next time, I will drink a water!

But, I dislike to drink the water with pills that make taste yuchy!

***~SG~*** · 08-21-2008, 08:20 AM

This is good information to read.

Matilda · 08-21-2008, 08:30 AM

Knew about the grapefruit but not the orange and apple juices.

Will be careful from now on.

Phillips · 08-21-2008, 08:35 AM

Very Interesting!!

Bottesini · 08-21-2008, 10:04 AM

That is interesting. I did know about grapefruit, but was surprised by the others.

CCfan · 08-21-2008, 10:23 AM

Quote:

Originally Posted by Matilda

Knew about the grapefruit but not the orange and apple juices.

Will be careful from now on.

Are you sure?

CCfan · 08-21-2008, 10:23 AM

Quote:

Originally Posted by Bottesini

That is interesting. I did know about grapefruit, but was surprised by the others.

I didn't know about that. But I know about orange since Vampy give
information to AD.

***Jolie77*** · 08-21-2008, 05:13 PM

This is an interesting information.

I knew fruit juices have vitamins in it, so with that, it'd make sense why it is powerful enough to be able to make those medications slow down or to shut it down.

Barbaro · 08-21-2008, 07:24 PM

I know this since very late 90's. My grandma has a heart condition and her doctor told her to not drink any juice, including OJ while taking her medication. She is allowed to eat any fruit. It is wonderful this article has been reported to pass medical knowledge to readers.

Matilda · 08-21-2008, 07:33 PM

Quote:

Originally Posted by CCfan

Are you sure?

Quote:

Originally Posted by CCfan

I didn't know about that. But I know about orange since Vampy give
information to AD.

... Come to think of it, I think I recall Vampy posting info on orange juice some time ago.

Pepsi · 08-25-2008, 12:12 PM

Thanks Vampy for the post.

08-20-2008, 05:22 PM	#3 (permalink)
CCfan Registered User Join Date: Nov 2005 Location: St. Paul, MN Posts: 924	Wow! Great info! Thanks so much for giving a very impro! VamPyroX! Next time, I will drink a water! But, I dislike to drink the water with pills that make taste yuchy! __________________ I am closed captioning fan.

08-21-2008, 08:20 AM	#4 (permalink)
*~SG~* Super Moderator Join Date: Jul 2003 Location: Australia Posts: 3,979	This is good information to read. __________________

08-21-2008, 08:35 AM	#6 (permalink)
Phillips Lets ride horses! Join Date: Aug 2006 Location: Spaceship Posts: 7,192 Blog Entries: 3	Very Interesting!! __________________ *Enjoy life today, Yesterday has past and Tomorrow may never come.*

08-21-2008, 10:04 AM	#7 (permalink)
Bottesini Elf Assassin Join Date: Mar 2008 Location: Sneaking up behind you Posts: 5,854 Blog Entries: 2	That is interesting. I did know about grapefruit, but was surprised by the others. __________________ AllDeaf

08-21-2008, 05:13 PM	#10 (permalink)
*Jolie77* Love all, trust a few. Join Date: Nov 2005 Location: Kentucky, USA (The Bluegrass State) Posts: 5,506	This is an interesting information. I knew fruit juices have vitamins in it, so with that, it'd make sense why it is powerful enough to be able to make those medications slow down or to shut it down. __________________

Today
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08-20-2008, 04:56 PM	#2 (permalink)
jillio Banned Join Date: Jun 2006 Posts: 21,197	Good info, Vampy.

08-21-2008, 08:30 AM	#5 (permalink)
Matilda Boxing Kangaroo "Jack" Join Date: Mar 2008 Location: Brisbane, Australia Posts: 2,176	Knew about the grapefruit but not the orange and apple juices. Will be careful from now on.

08-21-2008, 07:24 PM	#11 (permalink)
Barbaro doomsday clock's clicking Join Date: Jun 2007 Location: dæləs Posts: 305	I know this since very late 90's. My grandma has a heart condition and her doctor told her to not drink any juice, including OJ while taking her medication. She is allowed to eat any fruit. It is wonderful this article has been reported to pass medical knowledge to readers. __________________ We know what we are but not what we may be. -Author:Shakespeare

08-25-2008, 12:12 PM	#13 (permalink)
Pepsi The One and Only Join Date: Jun 2007 Location: USA Posts: 3,406	Thanks Vampy for the post. __________________

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