Improved nerve survival and controlled nerve fibre growth will benefit ci

neuro · 10-06-2009, 04:39 AM

"Improved nerve survival and controlled nerve fibre growth will benefit cochlear implant users by restoring nerve pathways and improving cochlear implant function".

"Site-specific gene transfer of neurotrophins in the cochlea for directing growth of regenerating neurons after deafness

Improving our ability to control the regeneration of nerves to the correct place

This is a three-year project led by Dr Rachael Richardson at the University of Melbourne. It will finish in March 2012.
Background

There is often a long interval between the onset of deafness and intervention, such as cochlear implantation. This interval results in degeneration of the auditory nerve and can mean that an implant is less effective. Nerve growth factors (neurotrophins) have been shown to rescue nerves from degeneration and cause regeneration. In a previous RNID-funded project, Dr Richardson and her team successfully introduced neurotrophins into the inner ear which encouraged nerves to re-grow. However, techniques need to be improved to allow more accurate guidance of the re-growing nerve to the place where it will be most useful.
Aim

The team proposes to use viral-mediated neurotrophin gene transfer to the organ of Corti within the cochlea (inner ear), where auditory nerve fibres terminate in normal cochleae. This will create a source of neurotrophins that can act as a directional cue to restore the highly structured organisation of auditory nerve fibres after deafness.
Benefit

Improved nerve survival and controlled nerve fibre growth will benefit cochlear implant users by restoring nerve pathways and improving cochlear implant function. The technology could also protect those at risk of hearing loss by protecting auditory nerves".
source: RNID.org.uk: How we help: Research and technology: Biomedical research: Our research: Projects archive: Restoring hearing

deafdude1 · 10-06-2009, 07:41 AM

I think you posted that before. This will be great for those who can't get to 25db or better with CI due to impairement of their auditory nerves. But everyone with CI still must have a functional auditory nerve or CI won't work. Stem cells can repair both your hair cells and nerves.

souggy · 10-06-2009, 07:44 AM

Replace "can" with "in theory, they could"

neuro · 10-06-2009, 08:22 AM

hi,
I wanted to comment that stem cells would also be valid for cochlear implants. Not for me, I'm not a cochlear implant. I think that if the stem cells is successful it would need a cochlear implant. But I also believe that cochlear implants would be better the functioning of the cochlear implant with the help of stem cells.
As the auditory nerve, I agree with you Deafdude, if the auditory nerve does not function well cochlear implant does not work, so also for those wishing to cochlear implant stem cells to regenerate would be possible to implement auditory nerve.
greetings

neuro · 10-06-2009, 08:26 AM

correction for translation problems:
if the stem cells is successful, the cochlear implant is not necessary, would be outdated the cochlear implant. If stem cells retrieved at least 20-30 dB improve the performance of hearing aids.

deafdude1 · 10-06-2009, 10:53 AM

Quote:

Originally Posted by neuro

correction for translation problems:
if the stem cells is successful, the cochlear implant is not necessary, would be outdated the cochlear implant. If stem cells retrieved at least 20-30 dB improve the performance of hearing aids.

CIs will be seen as a last resort just like ABIs are seen today. Stem cells will benefit the vast majority of people and give them enough hearing not to qualify for CI, which by the way will drastically tighten their candidacy requirements.

For those who already have CI(s) and a damaged auditory nerve, stem cells can repair their auditory nerve and improve their CI performance.

faire_jour · 10-06-2009, 12:02 PM

Quote:

Originally Posted by deafdude1

CIs (will be) could eventually be seen as a last resort just like ABIs are seen today. Stem cells (will benefit) hopefully could helpthe (vast majority of people) some people with hearing loss and (give them enough hearing not to qualify for CI) improve their hearing to some unknown degree, (which by the way will drastically tighten their candidacy requirements) which may help them to have better hearing, but we don't know if it will work in the long term, or if those hair cells will work well, or if they will also be damaged. Plus we have no idea what kinds of long term dangers there might be. We also don't know what knind of procedure it will take to get these stem cells, or if you would need tons of follow up, to keep the hearing working..

For those who already have CI(s) and a damaged auditory nerve, stem cells (can repair) could possibly help repair their auditory nerve and (improve their CI performance)......I don't know where he even got this last bit, so I don't have a correction for it.

Corrected for reality.

neuro · 10-09-2009, 04:25 AM

Improve Clinical Outcomes for Cochlear Implant Recipients By Mimicing the Viable Cochlear Environment To Induce Neural Stem Cells To Differentiate Into Auditory Neurons
Improve Clinical Outcomes for Cochlear Implant Recipients By... : Otology & Neurotology

10-06-2009, 04:39 AM	#1 (permalink)
neuro Banned Join Date: Aug 2009 Posts: 177	Improved nerve survival and controlled nerve fibre growth will benefit ci "Improved nerve survival and controlled nerve fibre growth will benefit cochlear implant users by restoring nerve pathways and improving cochlear implant function". "Site-specific gene transfer of neurotrophins in the cochlea for directing growth of regenerating neurons after deafness Improving our ability to control the regeneration of nerves to the correct place This is a three-year project led by Dr Rachael Richardson at the University of Melbourne. It will finish in March 2012. Background There is often a long interval between the onset of deafness and intervention, such as cochlear implantation. This interval results in degeneration of the auditory nerve and can mean that an implant is less effective. Nerve growth factors (neurotrophins) have been shown to rescue nerves from degeneration and cause regeneration. In a previous RNID-funded project, Dr Richardson and her team successfully introduced neurotrophins into the inner ear which encouraged nerves to re-grow. However, techniques need to be improved to allow more accurate guidance of the re-growing nerve to the place where it will be most useful. Aim The team proposes to use viral-mediated neurotrophin gene transfer to the organ of Corti within the cochlea (inner ear), where auditory nerve fibres terminate in normal cochleae. This will create a source of neurotrophins that can act as a directional cue to restore the highly structured organisation of auditory nerve fibres after deafness. Benefit Improved nerve survival and controlled nerve fibre growth will benefit cochlear implant users by restoring nerve pathways and improving cochlear implant function. The technology could also protect those at risk of hearing loss by protecting auditory nerves". source: RNID.org.uk: How we help: Research and technology: Biomedical research: Our research: Projects archive: Restoring hearing

10-06-2009, 07:41 AM	#2 (permalink)
deafdude1 Getting stem cells ~2011! Join Date: Feb 2009 Posts: 1,051 Blog Entries: 1	I think you posted that before. This will be great for those who can't get to 25db or better with CI due to impairement of their auditory nerves. But everyone with CI still must have a functional auditory nerve or CI won't work. Stem cells can repair both your hair cells and nerves. __________________

10-06-2009, 07:44 AM	#3 (permalink)
souggy Ear of a Doubt Join Date: Jul 2009 Location: Victoria, BC Posts: 2,403	Replace "can" with "in theory, they could" __________________ Souggy's Blog Warning! Contains skewed comments & inane ramblings. May cause spontaneous human combustion

10-09-2009, 04:25 AM	#8 (permalink)
neuro Banned Join Date: Aug 2009 Posts: 177	Improve Clinical Outcomes for Cochlear Implant Recipients By Mimicing the Viable Coch Improve Clinical Outcomes for Cochlear Implant Recipients By Mimicing the Viable Cochlear Environment To Induce Neural Stem Cells To Differentiate Into Auditory Neurons Improve Clinical Outcomes for Cochlear Implant Recipients By... : Otology & Neurotology

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10-06-2009, 08:22 AM	#4 (permalink)
neuro Banned Join Date: Aug 2009 Posts: 177	hi, I wanted to comment that stem cells would also be valid for cochlear implants. Not for me, I'm not a cochlear implant. I think that if the stem cells is successful it would need a cochlear implant. But I also believe that cochlear implants would be better the functioning of the cochlear implant with the help of stem cells. As the auditory nerve, I agree with you Deafdude, if the auditory nerve does not function well cochlear implant does not work, so also for those wishing to cochlear implant stem cells to regenerate would be possible to implement auditory nerve. greetings

10-06-2009, 08:26 AM	#5 (permalink)
neuro Banned Join Date: Aug 2009 Posts: 177	correction for translation problems: if the stem cells is successful, the cochlear implant is not necessary, would be outdated the cochlear implant. If stem cells retrieved at least 20-30 dB improve the performance of hearing aids.