kokonut

"Most recently, generation of new and functional auditory hair cells in the guinea pig cochlea was demonstrated using math1 delivered by an adenovector. Transvection of atoh1 in several model systems has been shown to be capable of generating hair cells, suggesting that atonal is a good candidate for further therpeutic development of inner ear disorders where re-establishment of sensory cells can elicit a clinical benefit. Examination of auditory hair cells that result from atonal therapy in vivo have identified some abnormal morpologic features, with cells having the characteristics of outer hair cells and supporting cells. This may suggest that genes that are active earlier in the devlopment of the sensory neuroepithelium function may be useful for restoring the inner ear. Manipulation of cell cycle control has also been demonstrated to result in restoration of auditory hair cells. Inhibition of hes1 and hes5 has also been demonstrated to generate supernumerary hair cells. Manipulation of several different development pathways can therefore be used to induce hair cell production. A therapeutic approach that allows the transformation of supporting cells into hair cells may be one effective way of restoring vestibular function."

Gene Therapy of Cochlear Deafness ... - Google Books

Getting closer that's for sure. That information was summarized in a book this year called "Gene Therapy of Cochlear Deafness: Present Concepts and Future Aspects" by A. F. Ryan.

Be sure to scroll down for more reports by others.

Deafness

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kokonut

This is the same Google link for 2009:

"More recently, the viability of gene therapy in human inner ear tissue has been reported."

Click on the link to go directly to the above quote.
Gene Therapy of Cochlear Deafness ... - Google Books

neuro

Gene Therapy for the Inner Ear: Challenges and Promises.......................................... .................................................. ..16
Gene Therapy in the Inner Ear Using Adenovirus Vectors........................................... .................................................. ...17
Gene Therapy and Stem Cell Transplantation: Strategies for Hearing Restoration. .................................................. .....17
Adenoviral and AAV-Mediated Gene Transfer to the Inner Ear: Role of Serotype, Promoter, and Viral
Load on In Vivo and In Vitro Infection Efficiencies. .................................................. .................................................. ........18
Cellular Targeting for Cochlear Gene Therapy........................................... .................................................. ......................18

source: http://www.clinigene.eu/pdf_e/190.pdf

neuro

preclinical or clinical??

"GenVec Inc. is a biopharmaceutical company engaged in developing novel gene-based therapeutic drugs and vaccines. The company’s product candidates TNFerade intended for the treatment of pancreatic cancer, AdPEDF for the treatment of macular degeneration and TherAtoh for hearing & balance loss are in clinical stages and utilize a common patent-protected technology platform".
source: PRMinds - GenVec, Inc. - Pharmaceuticals & Healthcare - Deals and Alliances Profile

jillio

as stated prior: preclinical.

neuro

"Positive Results For Hearing Loss & Balance Disorders. The underlying adenovector delivery technology has been proven safe in thousands of patients across a range of diseases and proof of concept of TherAtoh has been established in multiple preclinical models. The program is positioned to be quickly advanced into the clinic".
source: AllPennyStocks.com Company Spotlight - GenVec Inc. (Nasdaq:GNVC)

jillio

Key phrase:" is to be". That means in the future; hasn't happened yet.

neuro

no, the keyword is that rapid progress towards the clinic. In another message says that the program had been paralyzed, but due to subsidies will forward the program. Good Notica is currently seeking candidates human: "GenVec is currently in lead selection for the human candidate"

have to be optimistic. Is another option, genetics. We also have stem cells for example in China. We expect more cases treated, I hope. Beike is treating people with hearing loss ...

jillio

Perhaps it is because English is not your native language, but the phrase "to be" definitely refers to something that has not yet occurred, and may occur in the future.

neuro

currently??

neuro

Has / have been = present perfect

jillio

No, to be means it has not yet occurred. It may occur in the future. Otherwise the word "is" or "has been" would be applied.

jillio

I really don't think you want to attempt to correct my English, but "to be" is not present perfect. And you have altered the original post to read "has" and "has been". The original post contained the phrase "to be".

jillio

Progress toward the clinical means only that it is moving in that direction, not that it has gotten there.

neuro

well, may not be applied in humans right now, but can occur at any time, could be, but the important thing is to accelerate the clinical application, because if I do not think Beike seize the great economic pie or curing deafness less improve hearing.
We will be updated of what will happen or what is happening.

jillio

That is the whole point. It hasn't happened yet, and they do not know at what point in the future it will happen. So, preclinical is the correct phrase. And it is very dangerous to speed up the process to get to the clinical. That is when harm that has not been forseen happens to patients. That is why it is dangerous to accept the word of organizations like this.

neuro

But stem cells to treat deafness is happening, for example in China, and we expect more cases treated. The big news is that it is treatable, is being treated with stem cells, although it should be perfect. Genetics is another option, expect more news. But the stem cells in Beike is happening.

jillio

We only know that through anecdote. To date, there has been no published research finding coming out of Beike, or China in general. No published reasearch findings means chances are very great that false claims are being made, and people's lives are being risked.

neuro

So we expect more news

neuro

GenVec (theratoh) is true that in the preclinical phase, then the more immediate interest is in stem cells. GenVec Theratoh and falls behind, then win Beike and stem cells for now.

jillio

And that news will no doubt be years in coming, if proper research protocol is followed.

neuro

Every day we will share news, innovations, advances, congresses, days, little by little, for that there are innovations, increasingly innovations, which would be interesting to share. It is possible to comment on successes(wisdom) and failures(judgements). Of it we learn. Therefore it is interesting to comment on the information. We will see progresses undoubtedly.

deafdude1

Then we should email Beike and have them make the handful of cases where they treated deafness public. They made cases for other conditions public, including blindness.

__________________
My reasons for choosing stem cells over CI are numerous. Many thousands have gotten stem cells for all conditions with 90% success rate. I have emailed/contacted stem cell centers, read articles, did my research and know the facts. Chloe got such good results she can hear well without HAs! My hearing loss is the same in both ears. Recent audiogram: 125Hz=55db, 250Hz=70db, 500Hz=90db, 750Hz=110db, 1000Hz-8000Hz=NR at 110db. I discuss my deafness and stem cells in my blog

jillio

Be my guest. But I can assure you, if this research was valid and supportable, and had followed proper protocol, it would already have been published. We aren't talking public announcements that serve as advertisements from a webpage. We are talking about published research in professional publications.

neuro

Cell transplantation in hearing repair (otology seminar)
http://www.ntuh.gov.tw/ENT/DocLib3/C...2020080115.pdf

neuro

"I personally and strongly believe in stem cell research. There is a cure for anything all we have to do is seek and find. If scientists can do research and learn ways on how to cure diseases like diabetes, cancer, and Parkston's Disease. Some people believe that once you have the disease there is no cure, but now that we have a better president. President Obama will be funding money for stem cell research".
source: Teen Ink - All Opinion - My Beliefs

neuro

"Event Calendar Detail
Date & Time: Wednesday 10/28/2009 4:00 PM - 5:00 PM
Hosted By: MMG Department
Speaker: Neil Segil - Research Associate Professor
Cell and Neurobiology
University of Southern California
Subject: Development and Regeneration of the Inner Ear: Coordinating cell cycle and differentiation - Constraining Notch signaling
Location: Dr. S. Jerome & Judith D. Tamkin Student Lecture Building
F-114
Irvine, CA 92697
Contact: Mike Vo
Phone: (949) 824-7669
myv@uci.edu
Description:
MMG Department Seminar


Campus Map: http://today.uci.edu/pdf/UCI_06_Map.pdf (external link, opens new browser window) "

source: Events: Event Calendar Detail (external link, opens new browser window)"

source: RNID.org.uk: Community: Forums: Tinnitus forum: hair cells regeneration

neuro

also investigating the toxicity control and prevent tumors. For example there is a study in genetics:
"In Vitro and in Vivo Toxicity Studies on Block Copolymer Micelles: A Novel Nonviral Vector for Inner Ear Treatment"
2009; In Vitro and in Vivo Toxicity Studies on Block Copolymer Micelles: A Novel Nonviral Vector for Inner Ear Treatment

neuro

Recent advances in hair cell regeneration research

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692475/

neuro

"Most recently, we've had a leading-edge program in hearing loss
emerge. This program is also based on our core gene delivery
technology. Hearing loss is a major problem without effective drug
therapy, and we are excited about the potential our technology has to
address this serious unmet medical need".
source: GenVec, Inc. - Dr. Paul H. Fischer: Wall Street Transcript Interview Excerpt
or Yahoo! Message Boards - GenVec, Inc. (GNVC) - Company Interview Excerpt GenVec, Inc. - Dr. Paul H. Fischer